Nutritional Programming Affects Hypothalamic Organization and Early Response to Leptin
نویسندگان
چکیده
منابع مشابه
Hypothalamic Leptin Resistance: From BBB to BBSome.
In 1969, Douglas Coleman joined the bodies of an obese and a normal mouse by a procedure called parabiosis. Days later, the normal mouse starved. Something had taken away its desire to eat [1]. It was not until almost 25 years later that the true nature of what Coleman then called "satiety factor" was revealed. In 1994, Jeffrey Friedman identified the adipocytic hormone leptin [2,3] and it was ...
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Available data from both experimental and epidemiological studies suggest that inadequate diet in early life can permanently change the structure and function of specific organs or homoeostatic pathways, thereby 'programming' the individual's health status and longevity. Sufficient evidence has accumulated showing significant impact of epigenetic regulation mechanisms in nutritional programming...
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The hypothalamic paraventricular nucleus (PVN) plays a primary role in energy homeostasis, and urocortin (UCN) decreases feeding after injection into the PVN. Peripheral uncoupling proteins (UCPs) may influence energy metabolism. The effect of UCN administered into the PVN on UCPs is unknown. We injected PVN-cannulated rats with either UCN (200 pmol) or artificial cerebrospinal fluid (aCSF) at ...
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BACKGROUND Leptin, body weight, body mass index (BMI) and other hormones in women with functional hypothalamic amenorrhoea (FHA) were investigated and the hypothesis proposed that energy imbalance is the predominant mechanism for leptin reduction in patients with FHA. METHODS Eighty-eight women with FHA and 65 age- and weight-matched controls were divided into homogeneous groups on the basis ...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2010
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2009-0893